THE HEPATOPROTECTIVE EFFECTS OF THE METHANOLIC EXTRACT FROM THE PANDANUS ODORATISSIMUS FRUIT EXPRIMENTED ON THE SWISS STRAIN OF MICE
Corresponding Author(s) : Nguyen Cong Thuy Tram
UED Journal of Social Sciences, Humanities and Education,
Vol. 6 No. 1 (2016): UED JOURNAL OF SOCIAL SCIENCES, HUMANITIES AND EDUCATION
The hepatoprotective effects of the methanolic fruit extract from the Pandanus odoratissimus fruit have been shown from an experiment on Swiss mice infected with paracetamol. The methanolic extract (100, 200 and 300 mg/kg body weight/day) was given orally to the mice for seven consecutive days. On the 8th and 9th days of the experiment, the mice were intoxicated with paracetamol (3g/kg body weight/day). Silymarin was served as a reference agent. The research results showed that the methanolic extract from the Pandanus odoratissimus fruit had a hepatoprotective effect against paracetamol-induced liver damage. The livers of the mice receiving the testing dose of 100 mg/kg/day were better protected than the ones receiving 200, 300 mg/kg/day. The Pandanus odoratissimus fruit methanolic extract with a concentration of 100 mg/kg body weight/day was capable of decreasing the plasma activeness of the aspartate amino transferase enzyme (AST) and the alanine amino transferase (ALT) enzyme 1,76 times and 2,12 times respectively as well as reducing malondialdehyde (MDA) concentration in an experiment against the lipid peroxidation of cell membranes compared to the control group of mice
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 A.A.Oyagbemi and A.A.Odetola (2010), Hepatoprotective effects of Ethanolic extract of Cnidoscolus aconitifolius on paracetamol- Induced hepatic damage in Rats, Pakistan Journal of Biological Sciences 13(4), 164-169.
 Bộ Y tế (1996), Hướng dẫn nghiên cứu, đánh giá tính an toàn và hiệu lực thuốc Y học cổ truyền, Hà Nội.
 Nguyễn Mạnh Cường et al (2015), Chiết tác một số chất thuộc nhóm Phenolic từ quả cây Dứa dại Pandanus odoratissimus L.f., Tạp chí hóa học p. 432-435.
 David J. Newman, Gordon M. Cragg, and Kenneth M. Snader. (2003), “Natural products as sources of new drugs over the periode 1981-2002”, J. Nat. prod. 66, pp 1022-1037
 Dodehe Yeo, Rita Bouagnon, Bernard Nazaire Djyh, Chonta Tuo and Jean David N’guessan (2012), Acute and subacute toxic study of aqueous leaf extract of combretum molle. Tropical Journal of Pharmaceutical Research April; 11(2): 217-223.
 Đỗ Trung Đàm (2003), Phương pháp nghiên cứu độc tính cấp của thuốc, NXB Y học.
 Enika Nagababu et al (2011), Assessment of Antivities of Eugenol by in vitro and In vivo Methods, Methods Mol Biol, Author manuscript available in PMC.
 Hong-Jie Zhang et al (2001), Antimalarial Compounds from Rhaphidophora decursiva, Journal of Natural Products, 64, 772-777
 Hyo-Yeon Kim et al (2010), Hepatoprotective Effect of Pinoresinol on Carbon Tetrachloride – Induced Hepatic Damage in Mice, J. Pharmacol. Sci., 112, 105-112.
 M.U. Dianzani, G. Muzia, M.E. Biocca, R.A. Canuto (1991), Lipid peroxidation in fattyliver induced by caffeine in rats. International journal of tissue reactions 13, 79-85.
 S. Shahani (1999), Evaluation of hepatoprotectiveefficacy of APCL-A polyherbalformulation in vivo in rats, Indian Drugs 36, 628-631.
 Shetty Akhila J, Shyamjith Deepa and Alwar MC (2007), Actue toxicity studies and determination of median lethal dose, Current Science, 93(7): 917-920.